Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function
نویسندگان
چکیده
منابع مشابه
Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function.
Regulatory T cells (Tregs) are required for the maintenance of immune homeostasis as first clearly described by Herman Waldmann's laboratory. Dysfunction of Treg cells also leads to fatal autoimmunity in humans and mice. Conversely, the activation of different classes of Tregs operative systemically and within the cancer microenvironment can suppress host anti-tumor immune responses and promote...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-09211-3